Regenerative Medicine Utrecht

Linda van Laake, PhD

Assistant Professor
Cardiology
RMCU, UMC Utrecht
l.w.vanlaake@umcutrecht.nl

 

Dr. Van Laake is Assistant Professor and Cardiologist specialized in heart failure (European certification). She obtained her Medical Degree at Maastricht University in 2004 and her PhD at the Hubrecht Institute and UMCU, studying stem cell transplantation for cardiac regeneration. From 2007-2009 she did postdoctoral research on cardiac progenitor cells and microRNAs in heart repair at the University of California San Francisco with Prof. D. Srivastava.

In 2011 she was awarded a Veni grant by NWO to start her research line on circadian rhythms in heart repair and in 2012 she won the Heineken Young Scientist Award for Medicine, of the KNAW for her research accomplishments so far. Other research support includes a Netherlands Heart Foundation Dekker grant (2013), UMCU Clinical Research Talent Fellowship (2014) and a European Society of Cardiology Research Fellowship (2016).

Dr. Van Laake is active within the European Society of Cardiology (Nucleus Member of the Working Group on Cellular Biology of the Heart) and European Heart Failure Association (Member of the Translational Committee), and was a founding member of the Jonge Gezondheidsraad, an advisory body to the government and Parliament on the current level of knowledge with respect to public health issues and research.

Research

Cardiovascular disease is a major cause of morbidity and mortality throughout the world. Many cardiovascular diseases, such as heart failure and myocardial infarction, are associated with loss of functional cardiomyocytes (heart muscle cells). Since the heart has a limited regenerative capacity, it is not able to replace these cardiomyocytes on its own. Dr. Van Laake’s team explores novel approaches to regenerate the heart using stem- and progenitor cells. A focus on the understanding of fundamental cardiac developmental – and repair processes will promote the recapitulation of cardiac differentiation in vitro. Currently, the team is investigating the influence of circadian or “day-night” rhythms on cardiac development and regeneration.

“Using fluorescent and bioluminescent reporter systems, we are unraveling the physiological and pathophysiological meaning of circadian oscillations in cardiac progenitor cells and stem cell-derived cardiomyocytes in vitro and in vivo after transplantation in regenerative therapies. In addition, we study regeneration-related functional aspects of circadian oscillations in the normal and failing heart in humans and in mice. In vitro models of human heart tissue enable us to observe and manipulate the interaction of host and donor factors that are under control of the circadian clock.” Combing a variety of novel approaches together with a greater understanding of how heart development and repair work, Dr. Van Laake and her team strive to create better personalized heart failure therapies.

Selected Publications
Pubmed search: van Laake LW

L.W. Van Laake*, R. Madonna*, S.M. Davidson, F.B. Engel, D.J. Hausenloy, S. Lecour, J. Leor, C. Perrino, R. Schulz, K. Ytrehus, U. Landmesser, C.L. Mummery, S. Janssens, J. Willerson, T. Eschenhagen, P. Ferdinandy, J. P. Sluijter. Position Paper of the ESC Working Group Cellular Biology of the Heart: Cell-Based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure. European Heart Journal 2016; 37(23):1789-98.

P. Dierickx, B. Du Pré, D. Feyen, N. Geijsen, T. Van Veen, P.A. Doevendans, L.W. Van Laake. Circadian rhythms in stem cell biology and function. In: Stem Cell Biology and Regenerative Medicine, Springer. 2016:57-78.

B.C. Du Pré, T.A. van Veen, M.E. Young, M.A. Vos, P.A Doevendans, L.W. van Laake. Circadian rhythms in cell maturation. Physiology. 2014; 29(1):72-83.

L.W. van Laake*, L. Qian*, P. Chen, Y. Huang, E.C. Hsiao, B.R. Conklin, D. Srivastava. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circulation Research. 2010; 107(3):340-7

R. Passier, L.W. van Laake, C.L. Mummery. Cell therapy and lessons from the heart. Nature. 2008; 453(7193):322-9

Contact
Dr. Linda W. van Laake, MD, PhD
Regenerative Medicine Center, UMC Utrecht
mailto:l.w.vanlaake@umcutrecht.nl
+31 88 755 5555

Mailing address for correspondence
UMC Utrecht
E.03.511
P.O. Box 85500
3508 GA Utrecht
The Netherlands

Mailing address for packages
UMC Utrecht
E.03.511
Heidelberglaan 100
3584 CX Utrecht
The Netherlands